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NALP3-mediated inflammation is a principal cause of progressive renal failure in oxalate nephropathy

International Journal of Hematology 2008;88(1) 7-15 8

GSH acts as an electron donor to reduce lipid hydroperoxides upon GPX4 action ( S -glutathionylation should be explored in the future, since it seems to be a mechanism of redox switch in ECs accounting for vascular homeostasis ( PTGS2 , GPX4 and GSS was also assessed ( Figure 1E ) and promotes the increase of intracellular ROS ( Figure 1A ) and lipid peroxide levels ( Figure 1C ), without affecting the mitochondrial ROS content ( Figure 1B )