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The heparin-binding domain of extracellular superoxide dismutase C and formation of variants with reduced heparin affinity

Aug 23 2012;367(8):716-724

We critically evaluate clinical evidence across major liver diseases, including viral hepatitis, drug-induced liver injury, alcoholic liver disease, non-alcoholic fatty liver disease, and autoimmune hepatitis, while highlighting heterogeneity in study designs, geographical concentration of evidence, and the predominance of positive findings that may reflect publication bias

9,10 Mitochondria, which are critical for cellular respiration and metabolism, suffer damage to their own mitochondrial DNA by the actions of reactive oxygen species and peroxynitrite compounds, and they have been directly implicated in the process leading to cessation of ATP synthesis