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PT-141 nasal spray delivers bremelanotide through the nasal mucosa, where the peptide absorbs directly into systemic circulation bypassing first-pass metabolism like injectable administration but with significantly lower bioavailability (~30% nasal vs ~80-100% subcutaneous)

People who experience prolonged exposure to UV radiation during childhood, particularly if they experience severe sunburns, are thought to be more likely to develop melanomas and basal cell carcinomas later in life

The melanocortin pathway is well-characterised

For research focused only on the sexual pathway, PT-141 is the cleaner molecule without cutaneous side effects