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PLGA-based nanoparticles can cross the BBB by active processes namely receptor-mediated transcytosis (RMT) and carrier-mediated transport (CMT)

2 Mitochondrial dysfunction in ASD From a clinical point of view, mitochondrial dysfunction in ASD may be the cause of seizures, motor delay, fatigue and neurodevelopmental regression ( Mitochondrial dysfunction itself can be categorized into two types: the first type represents a mutation of a gene which is associated with the ATP-generating pathway, while the second one is related to various abnormalities such as genetic, biochemic or metabolic, that may weaken the ability of the mitochondria to produce ATP ( A central mechanism often implicated is the dysfunction of Electron Transport Chain (ETC), which plays a crucial role in ATP production

MRP7 Long MRP Role a lipophilic anion transporter, involved in phase III (cellular extrusion) of detoxification, does not directly transport GSH

Microbiol (Reading England) (2003) 149(Pt 3):66572