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suggest that the biopsy sample of lingual melanotic lesions include normal tissue so that it is easier to compare the normal pigmentation with that of the lesion.2 Although lingual melanotic macule is a benign condition, an important differential diagnosis is made with melanoma

(2009) documented the case of a 40-year-old male bodybuilder with a medical history of melanoma and multiple dysplastic nevi who reported using melanotan II for competition tan

Melanocytes can also function as neuroendocrine cells by producing acetylcholine, catecholamines, and POMC-derived peptides, which have the capacity to mediate local immunoinflammatory and antimicrobial responses and to modulate the biological behaviour of oral tissues [4]

finally prevent them