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The evidence demonstrating reduced BH4 availability in AD is the basis for the ongoing clinical trial based on the off-label (drug repurposing) use of BH4 (ClinicalTrials.gov, accessed on 15 March 2023)

Access this article Similar content being viewed by others Abbreviations -ECS: -Glutamylcysteine synthetase ABA: Abscisic acid APX: Ascorbate peroxidase AsA: Ascorbate CAT: Catalase Cys: Cysteine DHAR: Dehydroxyascorbate reductase Glu: Glutamine Gly I: Glyoxalase I (Lactoylglutathione lyase) Gly II: Glyoxalase II (Hydroxyacylglutathione hydrolase) GPX: Glutathione peroxidase GR: Glutathione reductase GSH: Glutathione GSHS: Glutathione synthase GSNO: S -Nitrosoglutathione GSSG: Glutathione disulfide GST: Glutathione S -transferase JA: Jasmonic acid MAP: Mitogen activated protein MDA: Malondialdehyde MG: Methylglyoxal NADPH: Nicotinamide adenine dinucleotide phosphate NO: Nitric oxide PC: Phytochelatin PCS: Phytochelatin synthase POD: Peroxidase ROS: Reactive oxygen species SA: Salicylic acid SLG: S -d-Lactoylglutathione SOD: Superoxide dismutase References Akter N, Sobahan MA, Uraji M, Ye W, Hossain MA, Mori IC, Nakamura Y, Murata Y (2012) Effects of depletion of glutathione on abscisic acid- and methyl jasmonate-induced stomatal closure in Arabidopsis thaliana

(1993) Therapy with Coenzyme Q10 for patients with periodontal disease

PrymaLab supplies it as a research-use-only 3ml autoinjector pen at 5mg/ml for in-vitro and non-human laboratory study