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Dual sources of melatonin and evidence for different primary functions

FIGURE 5 2.7 Pyroptosis Pyroptosisa lytic inflammatory cell death executed by gasdermin family protein-mediated nanoscale pore formationreleases pro-inflammatory cytokines (IL-1/IL-18) to amplify immune responses, with its molecular basis established through the identification of GSDMD as the executioner via caspase-1-mediated proteolysis (Rao et al., 2022) (Vasudevan et al., 2023) ( 2+ -dependent repair (Wei et al., 2022), whereas acute induction triggers immunogenic cell death through DAMPs and cytokines (IL-1/IL-18) that enhance dendritic/NK cell activation and cytotoxic T cell priming, reshaping immunosuppressive microenvironments (Wang et al., 2024) (Figure 6)

Madry et al., 2018)

To overcome the limitations of curcumins low bioavailability in clinical applications, various strategies have also been developed to enhance the utilization efficiency and pharmacological efficacy, including nano-delivery systems, chemical modifications and combination therapies