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Description

Without the natural ligand for the GHSR1a in many parts of the brain, the various roles of this receptor centrally remain uncertain

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De novo biosynthesis of GSH is controlled by the rate-limiting enzyme, glutamate-cysteine ligase (GCL, also known as -glutamylcysteine synthetase, -GCS) which consists of a catalytic (heavy) ( -GCSh) and a regulatory (light) subunit ( -GCSl)