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Future research could leverage single-cell RNA sequencing technology, combined with genomics, epigenomics, metabolomics and proteomics data, to comprehensively uncover the interaction networks between immune cells and chondrocytes in OA, thereby developing immune cell-based regulatory therapies

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no human cases confirmed) Long-term Safety: SELECT trial demonstrated 5+ year cardiovascular safety Key Difference: AOD-9604 may have a cleaner tolerability profile (no GI effects), but efficacy failure makes this advantage clinically irrelevant

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