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HO-1 is in charge of the oxidation of the heme groups free of ferrous iron (Fe2+), carbon monoxide, and biliverdin, the latter being reduced to bilirubin by biliverdin reductase, which acts as a fat-soluble antioxidant [32]

glutathione (r-glutamyl cysteingl +glycine (GSH)) is a tripeptide containing gamma-amide bonds and thiol groups, composed of glutamic acid, cysteine, and glycine, which is present in almost every cell of the body

This means that if you take more than your body needs, the excess is generally excreted in your urine, which is why B12 is considered very safe, even at high doses

Perhaps the added benefit of lopinavirs direct viral inhibition is enough to overcome IFNs off-target effects