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Pharmacogenomic research shows that genetic changes in drug-metabolizing enzymes, transporters, and targets can affect curcumins pharmacokinetics and pharmacodynamics

DON treatment decreases lactate and histone lysine lactylation (Kla) Glycolysis serves as the primary energy-supplying pathway in granulosa cells 37

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[36] The first step, and the rate-limiting enzyme in the salvage pathway is nicotinamide phosphoribosyltransferase (NAMPT), which produces nicotinamide mononucleotide (NMN)