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In contrast, manufacturers who offer overly optimistic promises without explaining their process often create unexpected problems later in the development cycle

For example, zwitterionic-based nanoparticles encapsulated by the mucolytic agent N -acetylcysteine have demonstrated enhanced mucus penetration, whereas the gradual release of N -acetylcysteine cleaves disulfide bonds within the mucus network, locally reducing its viscosity and further facilitating nanoparticle diffusion 194

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