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3f), confirming impaired fatty acid oxidation under sorafenib treatment

43: 26558 Tariq M, Morais C, Sobki S, et al

In normal physiological conditions, the organelle utilizes a variety of mechanisms to tightly regulate ROS (25)

Cystine starvation has been shown to impede TNBC growth, which affects stem cell properties and chemotherapy resistance in TNBC (27), thereby promoting TNBC cell ferroptosis through activation of the general control nonderepessible 2-eukaryotic translation initiation factor 2 subunit 1-activating transcription factor 4-CHAC1 pathway through the specific cytosolic GSH degradation enzyme CHAC1 (28)