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This rhythm, dictated largely by light exposure, ensures that certain bodily processes occur optimally during the day or night

Abraham SC, Krasinkas AM, Hofstetter WL, Swisher SG , and Wu TT

Genome-wide analyses reveal thousands of differentially methylated sites affecting steroid hormone signaling and inflammation pathways ( Histone modifiers are also dysregulated: histone deacetylases (HDAC1-3, SIRT1), methyltransferases (EZH2, MLL1), and demethylases (LSD1) alter chromatin states, contributing to progesterone resistance, inflammation, and fibrosis

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