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COVID-19 neurotropism and PD: exploring the links The CNS has been disrupted by COVID-19 in a variety of ways, including direct SARS-CoV-2 invasion of neuronal cells, huge inflammatory elements driven by severe systemic inflammation flowing into brains, respiratory failure linked brain ischemia, etc [18,19,20]

Numerous studies have shown that trace elements are closely related to the development of tumors ( ALL is a complex process involving multiple factors, genes, and stages ( The changing trend of trace elements in patients with ALL and its possible mechanism Zinc and ALL Zinc can act as a functional component or activator of many enzymes, and there are 18 known zinc enzymes and 14 other enzymes that require zinc to be activated

Mrp2 is probably the most widely studied MRP transporter, primarily because at least two MRP2-deficient rat models (Eisai hyperbilirubinuria rats and TR- rats) are available to study the role of MRP2 in drug disposition (Chen and Tiwari, 2011)