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Why is glutathione considered difficult to absorb

Study of Vitamin C Pharmacology The intravenous administration of high dose ascorbate (IVC) has increased in popularity among complementary and alternative medicine practitioners: thousands of patients received IVC, at an average dose of 0.5 g/kg, without significant side effects

Biochem Pharmacol 33: 29892994 Eck HP, Gmunder H, Hartmann M, Petzoldt D, Daniel V, Droge W (1989) Low concentrations of acidsoluble thiol (cysteine) in the blood plasma of HIV1infected patients

If this is high, it is a sign of poor phase II liver detoxification, and you want to boost glycine or reduce salicylates and benzoates