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However, the primary obstacle to the therapeutic effectiveness of these oligonucleotides is the blood-brain barrier (BBB), a crucial protective mechanism limiting drug penetration into brain cells

showed that human CD8 + cytotoxic T cells, when stimulated in vitro, produce significantly less interferon- and tumor necrosis factor- (TNF) in a glutamine-deprived environment, compared to a baseline glutamine-supplemented environment [150]

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