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Increased male hormone levels are a key feature of polycystic ovary syndrome and may result in excess facial and body hair, adult acne, and hair loss that resembles male-pattern baldness

In 1988, a putative homologue of the deaminase was identified in Streptomyces flocculus ( Streptomyces albus ATCC 13257) and proposed to be part of a major route in SAH metabolism, as SIH was isolated from the organism 16,17

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In a DSS-induced mouse model of colitis, these inhibitors demonstrated significant therapeutic efficacy without noticeable toxicity, suggesting that dual inhibition strategies may offer new perspectives for IBD treatment [465]