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Data Animal Data In pregnant rats given twice weekly subcutaneous doses of 0.02, 0.1, and 0.5 mg/kg tirzepatide [0.03-, 0.07-, and 0.5-fold the maximum recommended human dose (MRHD) of 15 mg once weekly based on AUC] during organogenesis, increased incidences of external, visceral, and skeletal malformations, increased incidences of visceral and skeletal developmental variations, and decreased fetal weights coincided with pharmacologically-mediated reductions in maternal body weights and food consumption at 0.5 mg/kg

Tirzepatide (Zepbound) is also FDA-approved for chronic weight management (with criteria) and has strong trial evidence for substantial average weight loss

SeekPeptides has analyzed the clinical trial data from both compounds extensively, and this guide breaks down everything researchers need to make an informed decision

Astrocytic activation is regulated by Bmal1 , shown through activation and increased inflammatory gene expression using an astrocyte specific Bmal1 knockout (Ali et al., 2020)