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[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Kurzawski M., Dziedziejko V., Urasiska E., Post M., Wjcicki M., Mitkiewski J., Drodzik M

10.1038/s41380-021-01073-6 137

For the uni, speed is another constraint, and I understand that you need shorter cranks to go fast, given a certain wheel-size

Together with previous work showing that perturbations of the N-terminal loop or -SNAP/Sec17 membrane engagement compromise SNARE complex disassembly and membrane fusion dynamics 11,37,38 , these findings support the idea that the M105I mutation may impair membrane fusion not only by diminishing plasma membrane binding, but also by diverting -SNAP into non-productive, off-pathway membrane contacts that cannot support a properly assembled 20S complex