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Thirdly, the current study focused on patients with MoCA scores below 26, and future research would benefit from including SCZ patients with minimal cognitive deficits (MoCA 2730) to provide a more comprehensive understanding of the relationship between ferroptosis markers and cognitive function in SCZ

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In thalassemia, unstable globin chains and excess free iron generate reactive oxygen species, which damage red blood cell membranes and shorten their lifespan

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AST/Bex also upregulated the expression of ABCA1, LRP1, and/or APOA-I, thereby facilitating cholesterol efflux partially through PPAR/RXR activation, and downregulated cholesterol biosynthesis and esterification

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