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HDIs structure and mechanism of action Histone deacetylase (HDAC) enzymes counter the activity of histone acetyltransferases by inducing hydrolysis of the -amino acetyl moiety on specific acetylated lysine residues within core histones (Figure 1A and B)

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The gene coding for human MET (Online Mendelian Inheritance in Man Code: 164860) is localized within the chromosome 7q31, which represents a common ASD linkage region