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And if you ever are willing to come out to Yale and do a series of events like we did with Mandy [Cohen], I am all in. Eric Topol: No, I would love to do that. Howard Forman: Thank you. Harlan Krumholz: Well even try to sell some books if you do. Eric Topol: All right

Despite significant progress in clinical RNAi drug development, there remains considerable room for improvement in pharmacokinetics, pharmacodynamics, and strategies to mitigate toxicity (Setten et al., 2019)

Despite these limitations, the guidelines do highlight the importance of a symptom-based approach and prioritise critical research initiatives to address many of the current shortcomings associated with the patient journey

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