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The top ten up-regulated proteins were involved in stress and unfolded protein response (corresponding genes: Gpx1 , Rrbp1 , Ranbp2 , Hspa5 , and Manf ) and DNA repair ( Nono ), and thus help to establish a balance between protein synthesis and degradation that promotes the survival of the cell

(Shanghai) 44 , 623 (2012)

This imbalance results in a reduction of antioxidants like glutathione, which can lead to the improper formation of disulfide bonds

This process is significant in numerous biological and pathological contexts and is implicated in the onset and progression of a wide array of human diseases