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Bispecific nanobody activity measured by macrophage phagocytosis Previous studies have demonstrated that PD-L1 antibodies can significantly enhance the proliferation and activation of macrophages in vivo, leading to a proinflammatory phenotype 29,30

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Mitochondrial function in adipocytes of lean or obese GSTA4-null mice was significantly compromised compared with wild-type controls and was accompanied by an increase in superoxide anion production

As well, natural compounds can increase the level of Microtubule-associated protein 1A/1B-light chain 3 (LC3-II), a marker of autophagy, that is decreased in PD which leads to the accumulation of -Syn aggregates (Wang et al