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These data also suggest that the naturally occurring, nonpsychotropic cannabinoid, cannabidiol, may be a potentially useful therapeutic agent for the treatment of oxidative neurological disorders such as cerebral ischemia. Another study done in 2000, Neuroprotective antioxidants from marijuana (Laboratory of Cellular and Molecular Regulation, NIMH, 2000) concluded: It was demonstrated that Cannabidiol, THC and other cannabinoids are potent antioxidants

However, some studies have shown inadequate levels of copper and manganese in the hippocampus in patients with MTLE and hippocampus sclerosis (MTLS-HS), while iron levels remain unaltered ( In summary, abnormal iron metabolism and distribution in the brain of epileptic patients might be one of the reasons for the occurrence and development of epilepsy

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We refer the reader to the FY 2020 IPPS/LTCH PPS final rule (84 FR 42292 through 42297) and the FY 2021 IPPS/LTCH PPS final rule (85 FR 58737 through 58739) for further discussion on this policy