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In preclinical studies, the efficacy of HMCD-drug conjugates is generally characterised in vitro , and mouse xenograft models are typically used to establish the biodistribution of the HMCD-conjugates in different organs

2024;187:1109-1126.e21

Several regions of the human brain, including the striatum, hippocampus, midbrain, olfactory bulb, spinal cord, and cerebral cortex, express G protein-coupled receptor 40 (GPR40), a form of polyunsaturated fatty acid (PUFA) receptor [63]