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Elevated levels of IgM and IgA antibodies to one potent MAMP- exotoxin lipopolysaccharide (LPS)- have been observed in ME/CFS (205), as well as higher blood levels of bacterial LPS, LPS-binding proteins, and soluble CD14 (191)

Kumar Pasupulati, A., Chitra, P

doi: 10.1016/0163-7258(91)90076-X 131 KietzmannTGrlachA

97,98,99 Vascular endothelial dysfunction further promotes the production of inflammatory mediators that disrupt the BBB, 59,63,64,100 which exposes the brain parenchyma to potentially neurotoxic proteins