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These practices not only increase the risk of ADRs but also intensify environmental selection pressure for resistant organisms, the combined effects of multiple pharmaceuticals (mixture toxicity) in the environment may produce synergistic or additive effects that are not predicted from single-compound assessments, representing a critical knowledge gapas noted by researchers such as Golding et al

Mice deficient in ceramide synthase 3 have a defective cornified lipid envelope and disrupted cutaneous barrier function and are susceptible to C

In autoimmune inflammatory illnesses, IL-23 is a related factor that can mediate inflammatory and immunological responses by T cells, NK cells, and macrophages (60)

Addressing these gaps will be essential to determine whether lipin-1 functions are intrinsically partitioned or instead dynamically integrated across macrophage states