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CVS and migraine, both, can be triggered by acute psychological or physiological stress, sleep deprivation and menses (27, 35, 63, 84), and a personal or family history of migraine disorders are frequent in both children and adults with CVS

Hartmut Jaeschke, a member of the Editorial Board of Exploration of Digestive Diseases, had no involvement in the decision-making or the review process of this manuscript

In skincare, glutathione has emerged as a significant brightening ingredient because of its multi-pathway melanin inhibition: it inhibits tyrosinase (reducing melanin synthesis), shifts melanogenesis from darker eumelanin towards lighter phaeomelanin (changing the type of melanin produced), and scavenges the free radicals and reactive oxygen species that trigger melanocyte melanin overproduction (addressing the upstream trigger of pigmentation)

Karon, B