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In addition, ARNTL2 knockdown decreases N-cadherin expression and increases the expression of -catenin and E-cadherin in lung adenocarcinoma cells, while the opposite effects are observed in ARNTL2-overexpressed cells, 118 suggesting that ARNTL2 overexpression may promote EMT by inhibiting ferroptosis

While the study was not designed to investigate age as a contributing factor, given the known inflammaging phenomenon, a brief exploratory analysis of the dataset investigating differences between aged ( 16 yr

Indeed, after longer time exposure, cell index slowly increases despite the presence of glutathione and cell number was not affected

Evidence suggests that ALA and DHLA increase ALDH2, enabling cells to detoxify aldehydes more effectively