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Description

The scheme in Fig

Well firstly, Im using an oral formulation of the molecule rather than an injectable one

Therefore, drugs with a high oral bioavailability are stable in the GI tract, are well absorbed and undergo minimal first-pass metabolism (Figure 2.2)

c-Met is overexpressed in multiple human cancers including gastric, lung, colorectal, and hepatocellular carcinoma, where aberrant HGF/c-Met signaling drives tumor growth, invasion, and metastasis