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The LAAM GSH-CQDs are composed of N-doped conjugated sp 2 carbons with a size of about 3.2 nm, surrounded by ~22 sterically hindered amino acid groups arranged alternately up and down at the edges

258,259 In addition to BM-MSC-Exos, other MSC-Exos were also reported to be efficacious in enhancing cartilage regeneration and preventing osteoarthritis

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Specifically, BPDE can induce global hypomethylation by inhibiting DNA methyltransferases (DNMTs), which leads to the upregulation of oncogene expression and downregulation of tumor suppressor gene function, thus promoting the proliferation and metastasis of bladder cancer cells (Bukowska and Siciska, 2021