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10.1186/s13046-020-01629-4 38 FinnR

Lessons Learned from Approval of Aducanumab for Alzheimers Disease

R.SatoS.AsamizuE.TabataS.RamosJ.et al (2003)

Discussion Here, we report the serendipitous identification of SP3N, a degrader of the prolyl isomerase FKBP12, which features a minimal design where the known FKBP12 ligand SLF is equipped with an alkylamine extension that conveys the observed degradation properties