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Coadministration of fluconazole 100 mg PO and hydrochlorothiazide 50 mg PO for 10 days in normal volunteers (n=13) resulted in a significant increase in fluconazole AUC and Cmax compared to fluconazole given alone

The larger concern is using supplements in place of diagnosis when low B12 is tied to GI disease

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A small randomized, double-blind, placebo-controlled study of a moderate-dose vitamin/mineral supplement was found to be beneficial to children with autism, primarily in the areas of sleep and gastrointestinal symptoms [14]