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Sox2 induces glioblastoma cell stemness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications

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Furthermore, elevated ammonia concentrations induce cytotoxic edema in astrocytes, initiating a cascade of oxidative stress responses within the brain parenchyma that ultimately lead to neuronal dysfunction and neurological impairment 1

doi: 10.1016/j.lfs.2021.119529 66 WuYZhaoYYangHZWangYJChenY