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Note: There is evidence that constituitively expressed COX-1 plays a role in mediating the acute onset of inflammatory responses, while inducible COX-2 plays a more major role in the chronic maintenance of inflammatory responses (Perrone et al, 2010)

Rascol, Olivier|Fitzer-Attas, Cheryl J|Hauser, Robert|Jankovic, Joseph|Lang, Anthony|Langston, J William|Melamed, Eldad|Poewe, Werner|Stocchi, Fabrizio|Tolosa, Eduardo|Eyal, Eli|Weiss, Yoni M|Olanow, C Warren A double-blind, delayed-start trial of rasagiline in Parkinson's disease (the ADAGIO study): prespecified and post-hoc analyses of the need for additional therapies, changes in UPDRS scores, and non-motor outcomes Lancet Neurology [14744422]