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Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation

This model was evaluated by: i) Serum ALT and bilirubin, ii) flow cytometry to define the immune cell composition in the liver and blood iii) H&E staining to assess steatosis, inflammation and ballooning iv) human/mouse aSMA and human Collagen-3 to asses mouse and human hepatic stellate cells activation and v) human CK8/18 to asses Mallory bodies formation