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In summary, these data suggest that glutathione plays a vital role in the detoxification of BH3 mimetics and that perturbation of GSH metabolism increases the sensitivity of AML cells towards BH3 mimetics

Tissue engineering and the intervertebral disc: The challenges

Brazilian J Pharm Sci 56:18

This work offers data for the significance of Nrf2 and its downstream genes in radioresistance in BCSCs and identifies processes by which the Nrf2/Keap1 pathway influences radioresistance in BCSCs ( Evidence gathered to date suggests that the upregulation of Nrf2 promotes tumor growth and survival by creating a favorable environment for cancer stem cells