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Pure cerebellar ataxia was presented in two cases, while five showed extracerebellar symptoms, including psychiatric symptoms (three case), cognitive dysfunction (two cases), generalized seizures (one case), and retinopathy (one case)

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Therefore, it seems that the lack of serine and glycine availability triggered by the inhibition of both extracellular and intracellular supplies of these amino acids (Supplementary Figure 1e) interrupts normal translation and prevents the induction of an ATF-4-mediated protective response

This helps ensure that the treatments are not causing harm and that they are providing the intended benefits