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Rapid mechanisms of glucocorticoid signaling in the Leydig cell

In several experimental models of autoimmune diseases (including thyroiditis), EVOO components, oleic acid, hydroxytyrosol, oleuropein, and oleocanthal, have proven effective in counteracting inflammatory and oxidative imbalances, suggesting their efficacy in preventing autoimmune diseases [62, 136, 137]

Vincristine, a chemotherapeutic agent, is known to cause neurotoxicity by decreasing levels of the antioxidant protein Nrf2 and its downstream targets HO-1 and NQO1