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The GLO-1 promoter region contains multiple regulatory elements that allow transcription factors like AP-2, AP-1, Nrf2, E2F4, and NF-B to enhance its activity, leading to increased GLO-1 expression

Endoplasmic reticulum stress is involved in hepatic SREBP-1c activation and lipid accumulation in fructose-fed mice

In one instance, enhanced receptor binding activity was observed (for an adenosine receptor agonist), and it was postulated that the pendant lipid molecule interacted with the phospholipid membrane to act as a distill anchor for the receptor ligand in the membrane micro environment of the receptor

Wang GL, Jiang BH, Rue EA, Semenza GL (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension