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doi:10.1158/1940-6207.CAPR-14-0386

The specific historical details in the opening paragraphs, including the 1975 origin, the second-year medical school account, and the name Substancija Boe Pomozi, are the product of that original reporting rather than established common knowledge

In contrast, drugs that are inhibitors of cytochrome P450 isozymes, e.g., antidepressants, may be expected to have little effect on valproate clearance because cytochrome P450 microsomal mediated oxidation is a relatively minor secondary metabolic pathway compared to glucuronidation and beta-oxidation