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NICE guidance emphasises the importance of investigating the underlying cause of B12 deficiency rather than simply treating with supplements, as this may identify serious conditions requiring specific management

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For researchers exploring alternatives to gavage, encapsulation remains the most reliable method to balance stress reduction, dose certainty, and taste elimination, provided the delayed absorption window is compatible with behavioral testing schedules

In sum, ctDCS responsiveness appears intrinsically state-dependent: the neurochemical milieu, inflammatory activity, and genetic background gate both the sign and magnitude of induced plasticity, offering a coherent explanation for the between- and within-subject heterogeneity observed to date