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ParkJLeeDGKimBParkSJKimJHLeeSRet al

Markedly elevated levels of estrone sulfate after long term oral, but not transdermal, administration of estradiol in postmenopausal women

Initially the imidazoles clotrimazole (containing 4 five membered organic ring and one chloride molecule), econazole (containing 3 five membered organic ring and three chloride molecule), miconazole (containing 3 five membered organic ring and 4 chloride molecule) were discovered but due to their toxicity on the host body they were utilized as topical administration as an alternative to nystatin to treat cutaneous and mucocutaneous