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Most positive findings come from animal studies Most of the encouraging data on peptides such as BPC-157 and TB-500 comes from rodent studies and isolated cell experiments looking at tendon and ligament healing

Role of acyl-CoA synthetase ACSL4 in arachidonic acid metabolism

References: Cox HD, Smeal SJ, Hughes CM, Cox JE, Eichner D

Furthermore, a 2-year, double-blind, randomized, placebo-controlled therapeutic trial in 158 healthy siblings of hyperhomocysteinemic patients with premature atherothrombotic disease folic acid plus vitamin B 6 treatment was associated with a decreased occurrence of abnormal exercise electrocardiography tests, which is consistent with a decreased risk of atherosclerotic events (Vermeulen et al, 2000)