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56 GongH.JiaoY.HuW.PuaE

DSIP# DSIP promotes delta-wave sleep through multiple pathways, none of which are fully characterized: Delta wave promotion -- increases the proportion of slow-wave sleep characterized by high-amplitude delta rhythms on EEG, the phenomenon for which it was named Serotonergic and GABAergic modulation -- sleep effects appear to involve modulation of both serotonin and GABA neurotransmission, the two major inhibitory systems involved in sleep initiation and maintenance NMDA receptor modulation -- may influence glutamatergic signaling involved in sleep-wake transitions CRF suppression -- reduces corticotropin-releasing factor, potentially lowering stress-related arousal that prevents sleep onset Neuroendocrine modulation -- affects the release of LH, GH, and ACTH at the hypothalamic level The fundamental distinction is that DSIP's mechanism remains undefined after more than 45 years of research

doi: 10.3390/biomedicines11040996 59 SeowAYuanJMSunCLVan Den BergDLeeHPYuMC

The biomechanics of this region are affected by the stiffness and thickness of the sclera that surrounds it and by glial deposition of ECM molecules (78)