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(For example, PDE-3 is the phosphodiesterase inhibited by pimobendan, thereby increasing cardiac contractility.) In a July 2018 article, medical researchers report finding that, "The combination of effects [of ITI-214] in both dog and rabbit results in a rise in cardiac output with negligible changes in cardiac preload and arterial systolic pressure." ITI-214 is a product of Intra-Cellular Therapies, Inc

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