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We were able to demonstrate this in NLCs by the efflux of calcein-AM with increasing BzATP (Fig

doi: 10.1172/JCI37662

Neuroprotective and neurotrophic actions: MC4 signaling is implicated in the regeneration and protection of peripheral nerves, as observed in experimental injury and neuropathy models 3

Collectively, these OFF-to-ON switching strategies illustrate therapeutic approaches in which GSH acts as a biological trigger for selective activation of cytotoxic agents in the GSH-rich tumor microenvironment