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Clinical trials have demonstrated that PHIs can enhance HIF activity, offering the potential to alleviate diabetes-induced kidney hypoxia (48)

62 LeeL.CampbellR.Scheuermann-FreestoneM.TaylorR.GunaruwanP.WilliamsL.et al (2005)

284,289 In addition, bare MSNs are less stable under the physiological ionic strength, are prone to aggregation, 290 and are rapidly removed from the circulation by nonspecific binding and uptake by the immune system

This might be due to the fact the SnCE1 tetramer being of moderate stability existing in an equilibrium with a monomeric state as shown by analytical SEC